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\nWhat’s different in their guts?\nDigging deeper, the researchers identified specific changes that occur in the composition of the gut microbiome of mice as they age. In particular, the relative abundance of a bacteria called Parabacteroides goldsteinii increases in old mice and is directly associated with cognitive decline in the animals. They showed that colonizing the guts of young mice with this bacterial species inhibited their performance on the object recognition and maze escape tasks, and that this deficit correlated with a reduction of activity in the hippocampus.